https://nova.newcastle.edu.au/vital/access/ /manager/Index en-au 5 https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:24776 Helicobacter pylori infection is considered to be causally linked to dyspepsia although only a minority will respond to eradication. In those with EPS, acid suppression therapy is a first line therapy; consider a H₂ blocker even if proton pump inhibitor fails. In PDS, a prokinetic is preferred. Second line therapy includes administration of a tricyclic antidepressant in low doses, or mirtazapine, but not a selective serotonin reuptake inhibitor.]]> Wed 15 Dec 2021 16:08:45 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:4538 Wed 11 Apr 2018 09:49:59 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:7214 Sat 24 Mar 2018 08:39:58 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:7216 Sat 24 Mar 2018 08:39:58 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:1055 Sat 24 Mar 2018 08:32:15 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:1167 Sat 24 Mar 2018 08:28:44 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:26272 Sat 24 Mar 2018 07:40:16 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:28490 Helicobacter pylori infection known to be an important precipitant of peptic ulcer disease in patients receiving non-steroidal anti-inflammatory drug therapy. The prevalence of H. pylori positivity in patients undergoing PCI and receiving subsequent antiplatelet therapy is unknown. Aims: We sought to determine the prevalence and features associated with H. pylori positivity in patients undergoing PCI. Methods: All patients undergoing PCI between August 2008 and April 2009 were identified and assessed for H. pylori positivity with serological status determined by using a commercially supplied enzyme- linked immunosorbent assay. Results: A total of 245 patients undergoing PCI during the study period had samples obtained for H. pylori serology. Of these, 91 were positive for H. pylori serology (37%) and 148 were negative (60%) with six samples being equivocal (3%). Of those patients positive for H. pylori, 75% were on agents at admission known to promote or precipitate gastrointestinal haemorrhage. Patients positive for H. pylori tended to be older, with increased creatinine and more likely to be receiving proton pump inhibitor therapy. Conclusions: In an unselected cohort of patients undergoing PCI in a single centre, we detected a prevalence of H. pylori positivity in 37% of patients; this denotes a potentially treatable precipitant of haemorrhage in a considerable portion of patients receiving dual antiplatelet therapy after PCI. Further prospective study is required to determine if the presence of H. pylori positivity is associated with adverse events in terms of gastrointestinal and cardiac outcomes.]]> Sat 24 Mar 2018 07:39:30 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:30117 Fri 01 May 2020 07:02:02 AEST ]]>